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NOTCH aberrations include frameshift and nonsense mutations leading to receptor truncations along with place substitutions in key functional domains that abrogate signaling in mobile-dependent assays. Oncogenic attain-of-functionality mutations in NOTCH1 frequently arise in human T-mobile lymphoblastic leukemia/lymphoma and B-mobile chronic lymphocytic leukemia. The bifunctional role of Notch in human most cancers Consequently emphasizes the context dependency of signaling outcomes and indicates that targeted inhibition of the Notch pathway may induce squamous epithelial malignancies. PubMed Disclaimer Conflict of fascination assertion The authors declare no conflict of curiosity.
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